Function of FXYD proteins, regulators of Na, K-ATPase

Details

Ressource 1Download: serval:BIB_E0189E3CC770.P001 (130.65 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_E0189E3CC770
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Function of FXYD proteins, regulators of Na, K-ATPase
Journal
Journal of Bioenergetics and Biomembranes
Author(s)
Geering  K.
ISSN
0145-479X (Print)
Publication state
Published
Issued date
12/2005
Volume
37
Number
6
Pages
387-92
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Dec
Abstract
In this short review, we summarize our work on the role of members of the FXYD protein family as tissue-specific modulators of Na, K-ATPase. FXYD1 or phospholemman, mainly expressed in heart and skeletal muscle increases the apparent affinity for intracellular Na(+) of Na, K-ATPase and may thus be important for appropriate muscle contractility. FXYD2 or gamma subunit and FXYD4 or CHIF modulate the apparent affinity for Na(+) of Na, K-ATPase in an opposite way, adapted to the physiological needs of Na(+) reabsorption in different segments of the renal tubule. FXYD3 expressed in stomach, colon, and numerous tumors also modulates the transport properties of Na, K-ATPase but it has a lower specificity of association than other FXYD proteins and an unusual membrane topology. Finally, FXYD7 is exclusively expressed in the brain and decreases the apparent affinity for extracellular K(+), which may be essential for proper neuronal excitability.
Keywords
Animals *Homeostasis Humans Intracellular Signaling Peptides and Proteins Membrane Glycoproteins Membrane Proteins Na(+)-K(+)-Exchanging ATPase/*physiology Neoplasm Proteins Nerve Tissue Proteins Organ Specificity Phosphoproteins Potassium Channels
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:28
Last modification date
01/10/2019 7:19
Usage data