Delirium and cognitive decline: more than a coincidence.

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State: Public
Version: author
Serval ID
serval:BIB_E00C946DF0AD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Delirium and cognitive decline: more than a coincidence.
Journal
Current Opinion in Neurology
Author(s)
Popp J.
ISSN
1473-6551 (Electronic)
ISSN-L
1350-7540
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
26
Number
6
Pages
634-639
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: To review the recent findings on the relationships between delirium and cognitive decline in the elderly.
RECENT FINDINGS: Current advances in the field include substantial new evidence that delirium increases the risk of dementia in patients without previous cognitive impairment and accelerates cognitive decline in patients with Alzheimer's disease. Findings on cognitive trajectories and domains affected contribute to better understanding of the clinical nature of cognitive impairment after delirium. Volume loss and disruption of white matter integrity may represent early MRI markers for long-term cognitive impairment. Neurodegenerative and low-level chronic inflammatory processes predispose to exaggerated response to incident stimuli that may precipitate both acute brain dysfunction and persisting cerebral damage.
SUMMARY: Still little is known about the relationship between delirium and cognitive trajectories in the elderly, and the underlying pathophysiological mechanisms. The association of neurodegenerative and inflammatory processes appears to play an important role in the pathogenesis and the clinical course of cognitive impairment after delirium. The hypothetical role of several other factors remains to be clarified. Further clinical studies are needed to evaluate whether prevention and treatment approaches that proved to be useful to reduce delirium incidence and severity may also improve long-term outcomes, and prevent cognitive decline.
Pubmed
Web of science
Create date
29/10/2013 12:47
Last modification date
20/08/2019 17:04
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