Phospholipids and other lipids in angiographically assessed coronary artery disease.

Details

Serval ID
serval:BIB_E002332AA7B0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Phospholipids and other lipids in angiographically assessed coronary artery disease.
Journal
Atherosclerosis
Author(s)
Bovet P., Darioli R., Essinger A., Golay A., Sigwart U., Kappenberger L.
ISSN
0021-9150
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
80
Number
1
Pages
41-47
Language
english
Notes
Journal Article --- Old month value: Nov
Abstract
Lipoprotein subclasses and their composition in cholesterol, triglycerides and in 5 types of phospholipid as well as apolipoproteins A-I and B were determined in blood of 114 patients undergoing coronary angiography for suspected or confirmed myocardial ischaemia. Lipid concentrations of lipoproteins were measured after preparative ultracentrifugation; high performance thin-layer chromatography was used to separate phospholipid subfractions. Patients with angiographically defined coronary artery disease (CAD) significantly differed from those without CAD in 25 different lipid or phospholipid parameters. Using discriminative analysis, apo A-I/apo B ratio was the only parameter with more than 70% success in reclassifying the patients in the CAD group. When correlated with a coronary atheromatous score reflecting either the number and degree of stenoses (Jenkins score) or the number of diseased vessels alone, only LDL-cholesterol was found to correlate with the Jenkins score. We conclude that serum phospholipid fractions may differ significantly in CAD group as compared with controls, but they are, however, no better predictors of CAD than other lipids.
Keywords
Adult, Aged, Angiography, Apolipoproteins, Cholesterol, Coronary Disease, Heart Catheterization, Humans, Lipids, Lipoproteins, Male, Middle Aged, Phospholipids
Pubmed
Web of science
Create date
28/01/2008 12:45
Last modification date
20/08/2019 17:04
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