GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

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Serval ID
serval:BIB_DFB754DDDD7C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.
Journal
European Journal of Neurology
Author(s)
Jasinska-Myga B., Wider C., Opala G., Krygowska-Wajs A., Barcikowska M., Czyzewski K., Baker M., Rademakers R., Uitti R.J., Farrer M.J., Ross O.A., Wszolek Z.K.
ISSN
1468-1331[electronic], 1351-5101[linking]
Publication state
Published
Issued date
2009
Volume
16
Number
8
Pages
909-911
Language
english
Abstract
BACKGROUND AND PURPOSE: A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN.
METHODS: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland.
RESULTS: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis).
CONCLUSIONS: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.
Keywords
Adult, Aged, Aged, 80 and over, European Continental Ancestry Group/genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Intercellular Signaling Peptides and Proteins/genetics, Male, Middle Aged, Parkinson Disease/epidemiology, Parkinson Disease/genetics, Poland/epidemiology, Polymorphism, Single Nucleotide, Risk Factors, United States/epidemiology, Young Adult
DOI
10.1111/j.1468-1331.2009.02621.x
Pubmed
19473366
Create date
24/09/2010 19:03
Last modification date
20/08/2019 17:04
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