Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors.
Details
Serval ID
serval:BIB_DFA99B5920FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors.
Journal
Yale Journal of Biology and Medicine
ISSN
0044-0086 (Print)
ISSN-L
0044-0086
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
71
Number
3-4
Pages
285-290
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
A series of 50 gastric endocrine tumors classified according to Rindi et al. [1] comprised 12 small cell neuroendocrine carcinomas (NEC) and 38 ECL cell carcinoids, of which 22 associated with type A chronic atrophic gastritis (A-CAG), eight with hypertrophic gastropathy due to combined Multiple Endocrine Neoplasia and Zollinger/Ellison syndrome (MEN/ZES), and eight sporadic. Variables found to predict tumor malignancy were: size > 2 cm, > 2 mitoses and > 130 Ki67 positive cells/10 high power fields (HPF), grade 2 or 3 histology, angioinvasion, p53 protein nuclear accumulation, and the presence of a single tumor. None of these factors increased significantly the predicting ability of tumor classification itself, although grade 2 + 3 shows 100 percent negative predictive value and Ki67 and angioinvasion 100 percent positive predictive value. When the mostly non-malignant A-CAG and MEN-ZES tumors were analysed against the mostly malignant sporadic and NEC tumors, a positive predictive value of 90 percent and a negative predictive value of 93 percent was obtained. Investigation of a larger tumor series is under way with the aim to develop an optimal model for prognostic evaluation of gastric endocrine tumors.
Keywords
Adult, Aged, Carcinoma/pathology, Cell Differentiation, Cell Division, Enterochromaffin-like Cells/metabolism, Enterochromaffin-like Cells/pathology, Female, Gastrins/metabolism, Gastritis, Atrophic/pathology, Humans, Male, Middle Aged, Mitosis, Neuroendocrine Tumors/classification, Neuroendocrine Tumors/pathology, Predictive Value of Tests, Regression Analysis, Serotonin/metabolism, Somatostatin/metabolism, Stomach Neoplasms/classification, Stomach Neoplasms/pathology
Pubmed
Web of science
Create date
07/09/2016 9:39
Last modification date
20/08/2019 17:04