Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.

Details

Serval ID
serval:BIB_DF82A9F1888A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.
Journal
Neurology
Author(s)
Ntaios G., Perlepe K., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Koroboki E., Manios E., Makaritsis K., Michel P., Vemmos K.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Publication state
Published
Issued date
04/06/2019
Peer-reviewed
Oui
Volume
92
Number
23
Pages
e2644-e2652
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To investigate the association between the presence of ipsilateral nonstenotic carotid plaques and the rate of detection of atrial fibrillation (AF) during follow-up in patients with embolic strokes of undetermined source (ESUS).
We pooled data of all consecutive ESUS patients from 3 prospective stroke registries. Multivariate stepwise regression assessed the association between the presence of nonstenotic carotid plaques and AF detection. The 10-year cumulative probabilities of AF detection were estimated by the Kaplan-Meier product limit method.
Among 777 patients followed for 2,642 patient-years, 341 (38.6%) patients had an ipsilateral nonstenotic carotid plaque. AF was detected in 112 (14.4%) patients in the overall population during follow-up. The overall rate of AF detection was 8.5% in patients with nonstenotic carotid plaques (2.9% per 100 patient-years) and 19.0% in patients without (5.0% per 100 patient-years) (unadjusted hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.37-0.84). The presence of ipsilateral nonstenotic carotid plaques was associated with lower probability for AF detection (adjusted HR 0.57, 95% CI 0.34-0.96, p = 0.03). The 10-year cumulative probability of AF detection was lower in patients with ipsilateral nonstenotic carotid plaques compared to those without (34.5%, 95% CI 21.8-47.2 vs 49.0%, 95% CI 40.4-57.6 respectively, log-rank-test: 11.8, p = 0.001).
AF is less frequently detected in ESUS patients with nonstenotic carotid plaques compared to those without.
NCT02766205.
Keywords
Aged, Aged, 80 and over, Atrial Fibrillation/epidemiology, Carotid Artery Diseases/epidemiology, Female, Humans, Intracranial Embolism/epidemiology, Male, Middle Aged, Plaque, Atherosclerotic/epidemiology, Proportional Hazards Models, Stroke/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2019 13:01
Last modification date
04/01/2020 7:17
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