A database to aid the identification of chemicals potentially posing a health risk through percutaneous exposure

Details

Serval ID
serval:BIB_DF6A3CF03BB2
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
A database to aid the identification of chemicals potentially posing a health risk through percutaneous exposure
Title of the conference
Occupational and Environmental Exposure of the Skin to Chemicals 2009, 14th-17th June , 2009
Author(s)
Lavoué Jérôme, Milon Antoine
Publisher
British Occupational Hygiene Society
Address
Derby
Publication state
Published
Issued date
2009
Pages
36
Language
english
Notes
SAPHIRID:80568
Abstract
In the context of recent attempts to redefine the 'skin notation' concept, a position paper summarizing an international workshop on the topic stated that the skin notation should be a hazard indicator related to the degree of toxicity and the potential for transdermal exposure of a chemical. Within the framework of developing a web-based tool integrating this concept, we constructed a database of 7101 agents for which a percutaneous permeation constant can be estimated (using molecular weight and octanol-water partition constant), and for which at least one of the following toxicity indices could be retrieved: Inhalation occupational exposure limit (n=644), Oral lethal dose 50 (LD50, n=6708), cutaneous LD50 (n=1801), Oral no observed adverse effect level (NOAEL, n=1600), and cutaneous NOAEL (n=187). Data sources included the Registry of toxic effects of chemical substances (RTECS, MDL information systems, Inc.), PHYSPROP (Syracuse Research Corp.) and safety cards from the International Programme on Chemical Safety (IPCS). A hazard index, which corresponds to the product of exposure duration and skin surface exposed that would yield an internal dose equal to a toxic reference dose was calculated. This presentation provides a descriptive summary of the database, correlations between toxicity indices, and an example of how the web tool will help industrial hygienist decide on the possibility of a dermal risk using the hazard index.
Keywords
Skin , Skin Absorption , Risk Assessment , Threshold Limit Values , Occupational Exposure
Create date
27/01/2010 12:20
Last modification date
20/08/2019 16:03
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