NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.

Details

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Serval ID
serval:BIB_DF61EFC56003
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
UNIL/CHUV
Title
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.
Journal
Molecular cell
Author(s)
Bernard E.M., Broz P.
ISSN
1097-4164 (Electronic)
ISSN-L
1097-2765
Publication state
Published
Issued date
03/08/2023
Peer-reviewed
Oui
Volume
83
Number
15
Pages
2621-2623
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Comment
Publication Status: ppublish
Abstract
Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al. <sup>1</sup> implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.
Keywords
Humans, Heme/metabolism, Pathogen-Associated Molecular Pattern Molecules, Inflammation/metabolism, Immunity, Innate, Hemolysis, Necrosis, Cell Death, Intracellular Signaling Peptides and Proteins
OAI-PMH
oai:serval.unil.ch:BIB_DF61EFC56003
DOI
10.1016/j.molcel.2023.07.005
Pubmed
37541218
Create date
10/08/2023 13:24
Last modification date
18/08/2023 5:57
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