Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3 T.

Details

Serval ID
serval:BIB_DF5C2AD55C28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3 T.
Journal
Human Brain Mapping
Author(s)
Granziera C., Daducci A., Romascano D., Roche A., Helms G., Krueger G., Hadjikhani N.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
35
Number
4
Pages
1461-1468
Language
english
Notes
EPFL-ARTICLE-181642
Abstract
BACKGROUND AND OBJECTIVES: The thalamus exerts a pivotal role in pain processing and cortical excitability control, and migraine is characterized by repeated pain attacks and abnormal cortical habituation to excitatory stimuli. This work aimed at studying the microstructure of the thalamus in migraine patients using an innovative multiparametric approach at high-field magnetic resonance imaging (MRI).
DESIGN: We examined 37 migraineurs (22 without aura, MWoA, and 15 with aura, MWA) as well as 20 healthy controls (HC) in a 3-T MRI equipped with a 32-channel coil. We acquired whole-brain T1 relaxation maps and computed magnetization transfer ratio (MTR), generalized fractional anisotropy, and T2* maps to probe microstructural and connectivity integrity and to assess iron deposition. We also correlated the obtained parametric values with the average monthly frequency of migraine attacks and disease duration.
RESULTS: T1 relaxation time was significantly shorter in the thalamus of MWA patients compared with MWoA (P < 0.001) and HC (P ≤ 0.01); in addition, MTR was higher and T2* relaxation time was shorter in MWA than in MWoA patients (P < 0.05, respectively). These data reveal broad microstructural alterations in the thalamus of MWA patients compared with MWoA and HC, suggesting increased iron deposition and myelin content/cellularity. However, MWA and MWoA patients did not show any differences in the thalamic nucleus involved in pain processing in migraine.
CONCLUSIONS: There are broad microstructural alterations in the thalamus of MWA patients that may underlie abnormal cortical excitability control leading to cortical spreading depression and visual aura.
Keywords
Adult, Anisotropy, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Migraine with Aura/pathology, Migraine without Aura/pathology, Multivariate Analysis, Thalamus/pathology
Pubmed
Web of science
Create date
20/06/2014 17:35
Last modification date
20/08/2019 16:03
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