Mitomycin C for control of recurrent bronchial stenosis: a case report.

Details

Serval ID
serval:BIB_DF4DEAC5D563
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Mitomycin C for control of recurrent bronchial stenosis: a case report.
Journal
Chest
Author(s)
Erard A.C., Monnier P., Spiliopoulos A., Nicod L.
ISSN
0012-3692[print], 0012-3692[linking]
Publication state
Published
Issued date
2001
Volume
120
Number
6
Pages
2103-2105
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
A 27-year-old patient with cystic fibrosis underwent a bilateral lung transplantation despite the presence of multiresistant Burkholderia cepacia. Postoperatively, the patient presented with bilateral bronchial necrosis. During the 14th week, his FEV(1) dropped to 2.5 L from a baseline level of 3.4 L. A subtotal occlusion of the right mainstem bronchus below the suture was noted. Using argon electrocoagulation, the right upper lobe bronchus, the intermediate bronchus, and the right middle lobe bronchus were reopened. During the period between weeks 20 and 42 post-transplantation, a recurrent stenosis required eight endoscopic interventions combining dilatation and stenting. During the 42nd week, dilatation followed by mitomycin C application stabilized the right lung function. This case report is the first to describe the effectiveness of the local application of mitomycin C to stop recurring extensive bronchial stenosis following bronchial necrosis secondary to lung transplantation.
Keywords
Administration, Topical, Adult, Airway Obstruction/drug therapy, Bronchi/pathology, Bronchial Diseases/drug therapy, Cystic Fibrosis/surgery, Dilatation, Humans, Lung Transplantation, Male, Mitomycin/administration & dosage, Mitomycin/adverse effects, Necrosis, Recurrence
Pubmed
Web of science
Create date
19/02/2010 20:01
Last modification date
20/08/2019 17:03
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