Immune consequences of exercise in hypoxia: A narrative review.

Details

Ressource 1Download: 423. Burtscher JSHS23ip ImmuneConsequence Exercise Hypoxia - review.pdf (2565.87 [Ko])
State: Public
Version: Author's accepted manuscript
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_DEFC399FCB7C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immune consequences of exercise in hypoxia: A narrative review.
Journal
Journal of sport and health science
Author(s)
Burtscher J., Pasha Q., Chanana N., Millet G.P., Burtscher M., Strasser B.
ISSN
2213-2961 (Electronic)
ISSN-L
2213-2961
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Immune outcomes are key mediators of many health benefits of exercise and are determined by exercise type, dose (frequency/duration, intensity), and individual characteristics. Similarly, reduced availability of ambient oxygen (hypoxia) modulates immune functions depending on the hypoxic dose and the individual capacity to respond to hypoxia. How combined exercise and hypoxia (e.g., high-altitude training) sculpts immune responses is not well understood, although such combinations are becoming increasingly popular. Therefore, in this paper, we summarize the impact on immune responses of exercise and of hypoxia, both independently and together, with a focus on specialized cells in the innate and adaptive immune system. We review the regulation of the immune system by tissue oxygen levels and the overlapping and distinct immune responses related to exercise and hypoxia, then we discuss how they may be modulated by nutritional strategies. Mitochondrial, antioxidant, and anti-inflammatory mechanisms underlie many of the adaptations that can lead to improved cellular metabolism, resilience, and overall immune functions by regulating the survival, differentiation, activation, and migration of immune cells. This review shows that exercise and hypoxia can impair or complement/synergize with each other while regulating immune system functions. Appropriate acclimatization, training, and nutritional strategies can be used to avoid risks and tap into the synergistic potentials of the poorly studied immune consequences of exercising in a hypoxic state.
Keywords
Altitude, Exercise, Hypoxia, Immune response, Training
Pubmed
Open Access
Yes
Create date
29/09/2023 14:09
Last modification date
23/01/2024 7:14
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