In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.

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Serval ID
serval:BIB_DEEE58BD8725
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.
Journal
The Journal of Infectious Diseases
Author(s)
Bourreau E., Ronet C., Darsissac E., Lise M.C., Marie D.S., Clity E., Tacchini-Cottier F., Couppie P., Launois P.
ISSN
0022-1899
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
199
Number
4
Pages
576-579
Language
english
Abstract
The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.
Keywords
Adolescent, Adult, Animals, Antiprotozoal Agents/therapeutic use, Female, Forkhead Transcription Factors/genetics, Forkhead Transcription Factors/metabolism, Gene Expression Regulation, Humans, Interleukin-10/genetics, Interleukin-10/metabolism, Leishmania guyanensis/drug effects, Leishmaniasis, Cutaneous/drug therapy, Leishmaniasis, Cutaneous/immunology, Male, Middle Aged, Pentamidine/therapeutic use, RNA, Messenger/genetics, RNA, Messenger/metabolism, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Treatment Failure
Pubmed
Web of science
Open Access
Yes
Create date
17/08/2009 13:13
Last modification date
01/10/2019 7:19
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