Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents.

Details

Serval ID
serval:BIB_DEE79712496B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents.
Journal
European journal of clinical nutrition
Author(s)
Ginty F., Cavadini C., Michaud P.A., Burckhardt P., Baumgartner M., Mishra G.D., Barclay D.V.
ISSN
0954-3007
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
58
Number
9
Pages
1257-65
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
OBJECTIVE: To evaluate the effects of nutrient intake and vitamin D status on markers of type I collagen formation and degradation in adolescent boys and girls. DESIGN: Cross-sectional study. SETTING: Canton of Vaud, West Switzerland. SUBJECTS: A total of 92 boys and 104 girls, aged 11-16 y. Data were collected on height, weight, pubertal status (self-assessment of Tanner stage), nutrient intake (3-day dietary record) and fasting serum concentration of 25-hydroxyvitamin D (25OHD), and markers of collagen formation (P1NP) and degradation (serum C-terminal telopeptides: S-CTX). RESULTS: Tanner stage was a significant determinant of P1NP in boys and girls and S-CTX in girls. Of the nutrients examined, only the ratio of calcium to phosphorus (Ca/P) was positively associated with P1NP in boys, after adjustment for pubertal status. 25OHD decreased significantly at each Tanner stage in boys. Overall, 15% of boys and 17% of girls were identified as being vitamin D insufficient (serum 25OHD <30 nmol/l), with the highest proportion of insufficiency at Tanner stage 4-5 (29%) in boys and at Tanner stage 3 (24%) in girls. A significant association was not found between 25OHD and either bone turnover marker, nor was 25OHD insufficiency associated with higher concentrations of the bone turnover markers. CONCLUSIONS: The marked effects of puberty on bone metabolism may have obscured any possible effects of diet and vitamin D status on markers of bone metabolism. The mechanistic basis for the positive association between dietary Ca/P ratio and P1NP in boys is not clear and may be attributable to a higher Ca intake per se, a critical balance between Ca and P intake or higher dairy product consumption. A higher incidence of vitamin D insufficiency in older adolescents may reflect a more sedentary lifestyle or increased utilisation of 25OHD, and suggests that further research is needed to define their requirements. SPONSORSHIP: Nestec Ltd and The Swiss Foundation for Research in Osteoporosis.
Keywords
Adolescent, Bone and Bones, Calcium, Child, Collagen, Cross-Sectional Studies, Diet Records, Female, Food Habits, Humans, Male, Nutritional Requirements, Nutritional Status, Peptide Fragments, Phosphorus, Procollagen, Puberty, Switzerland, Vitamin D, Vitamin D Deficiency
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 16:57
Last modification date
20/08/2019 17:03
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