Constant regulation for stable CD8 T-cell functional avidity and its possible implications for cancer immunotherapy.

Details

Serval ID
serval:BIB_DE9645D7CF3A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Constant regulation for stable CD8 T-cell functional avidity and its possible implications for cancer immunotherapy.
Journal
European journal of immunology
Author(s)
Gilfillan C.B., Hebeisen M., Rufer N., Speiser D.E.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional capabilities and correlates with protection from infection and cancer. FA depends on TCR affinity, downstream signaling strength, and TCR affinity-independent parameters of the immune synapse, such as costimulatory and inhibitory receptors. The functional impact of coreceptors on FA remains to be fully elucidated. Despite its importance, FA is infrequently assessed and incompletely understood. There is currently no consensus as to whether FA can be enhanced by optimized vaccine dose or boosting schedule. Recent findings suggest that FA is remarkably stable in vivo, possibly due to continued signaling modulation of critical receptors in the immune synapse. In this review, we provide an overview of the current knowledge and hypothesize that in vivo, codominant T cells constantly "equalize" their FA for similar function. We present a new model of constant FA regulation, and discuss practical implications for T-cell-based cancer immunotherapy.
Keywords
CD8 T cells, TCR affinity, avidity regulation, co-receptors, functional avidity, coreceptors
Pubmed
Web of science
Open Access
Yes
Create date
29/03/2021 11:47
Last modification date
17/04/2021 6:33
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