The Evolution of Cortical and Sub-cortical Lesion Size and Number Correlates with Changes in Cognition in Early-Stage Relapsing-Remitting Multiple Sclerosis Patients

Details

Serval ID
serval:BIB_DE7A3632558E
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
The Evolution of Cortical and Sub-cortical Lesion Size and Number Correlates with Changes in Cognition in Early-Stage Relapsing-Remitting Multiple Sclerosis Patients
Title of the conference
Proceedings of 25th Annual Meeting of Intl. Soc. Mag. Reson. Med (ISMRM)
Author(s)
Sorega A., Fartaria MJ., Bonnier G., Kober T., Du Pasquier R., Schluep M., Krueger G., Bach Cuadra M., Granziera C.
Publication state
Published
Issued date
22/04/2017
Peer-reviewed
Oui
Language
english
Abstract
Lesion load and activity in multiple sclerosis (MS) patients, as identified by conventional magnetic resonance imaging (MRI), correlate only moderately with patients clinical status and evolution. Cortical lesion number and volume measured with advanced MRI may provide better correlates to cognitive dysfunction and disability. In this work, we studied the clinical impact of advanced MRI metrics of cortical and subcortical lesion evolution in a cohort of early relapsing-remitting MS patients. The number and volume of lesions that “shrunk”, disappeared or remained stable over time were strong determinants of changes in cognition in our patients cohort.
Create date
12/02/2018 18:12
Last modification date
21/08/2019 6:33
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