Novelties in treatment of locally advanced rectal cancer.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_DE32F2C5FC58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Novelties in treatment of locally advanced rectal cancer.
Journal
F1000Research
Author(s)
Grass F., Mathis K.
ISSN
2046-1402 (Electronic)
ISSN-L
2046-1402
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
7
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Treatment of locally advanced rectal cancer is evolving through surgical innovation and paradigm shifts in neoadjuvant treatment. Whereas local recurrence was a significant concern before the systematic implementation of neoadjuvant chemoradiation therapy and surgery according to total mesorectal excision principles, distant relapse remains a major drawback. Hence, efforts in recent years have focused on delivering preoperative chemotherapy regimens to overcome compliance issues with adjuvant administration. In parallel, new surgical techniques, including transanal video-assisted total mesorectal excision and robot-assisted surgery, emerged to face the challenge to navigate in the deep and narrow spaces of the pelvis. Furthermore, patients experiencing a complete response after neoadjuvant treatment might even escape surgery within a close surveillance strategy. This novel "watch and wait" concept has gained interest to improve quality of life in highly selected patients. This review summarizes recent evidence and controversies and provides an overview on timely and innovative aspects in the treatment of locally advanced rectal cancer.
Keywords
Animals, Humans, Monitoring, Physiologic, Neoadjuvant Therapy/methods, Neoplasm Recurrence, Local/therapy, Rectal Neoplasms/therapy, Rectal cancer, neoadjuvant, surgery, treatment, watch and wait
Pubmed
Open Access
Yes
Create date
29/11/2021 13:42
Last modification date
30/11/2021 7:13
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