GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

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State: Public
Version: author
Serval ID
serval:BIB_DE32A3661286
Type
Article: article from journal or magazin.
Collection
Publications
Title
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
Journal
Science
Author(s)
Rietveld C.A., Medland S.E., Derringer J., Yang J., Esko T., Martin N.W., Westra H.J., Shakhbazov K., Abdellaoui A., Agrawal A., Albrecht E., Alizadeh B.Z., Amin N., Barnard J., Baumeister S.E., Benke K.S., Bielak L.F., Boatman J.A., Boyle P.A., Davies G., de Leeuw C., Eklund N., Evans D.S., Ferhmann R., Fischer K., Gieger C., Gjessing H.K., Hägg S., Harris J.R., Hayward C., Holzapfel C., Ibrahim-Verbaas C.A., Ingelsson E., Jacobsson B., Joshi P.K., Jugessur A., Kaakinen M., Kanoni S., Karjalainen J., Kolcic I., Kristiansson K., Kutalik Z., Lahti J., Lee S.H., Lin P., Lind P.A., Liu Y., Lohman K., Loitfelder M., McMahon G., Vidal P.M., Meirelles O., Milani L., Myhre R., Nuotio M.L., Oldmeadow C.J., Petrovic K.E., Peyrot W.J., Polasek O., Quaye L., Reinmaa E., Rice J.P., Rizzi T.S., Schmidt H., Schmidt R., Smith A.V., Smith J.A., Tanaka T., Terracciano A., van der Loos M.J., Vitart V., Völzke H., Wellmann J., Yu L., Zhao W., Allik J., Attia J.R., Bandinelli S., Bastardot F., Beauchamp J., Bennett D.A., Berger K., Bierut L.J., Boomsma D.I., Bültmann U., Campbell H., Chabris C.F., Cherkas L., Chung M.K., Cucca F., de Andrade M., De Jager P.L., De Neve J.E., Deary I.J., Dedoussis G.V., Deloukas P., Dimitriou M., Eiríksdóttir G., Elderson M.F., Eriksson J.G., Evans D.M., Faul J.D., Ferrucci L., Garcia M.E., Grönberg H., Guðnason V., Hall P., Harris J.M., Harris T.B., Hastie N.D., Heath A.C., Hernandez D.G., Hoffmann W., Hofman A., Holle R., Holliday E.G., Hottenga J.J., Iacono W.G., Illig T., Järvelin M.R., Kähönen M., Kaprio J., Kirkpatrick R.M., Kowgier M., Latvala A., Launer L.J., Lawlor D.A., Lehtimäki T., Li J., Lichtenstein P., Lichtner P., Liewald D.C., Madden P.A., Magnusson P.K., Mäkinen T.E., Masala M., McGue M., Metspalu A., Mielck A., Miller M.B., Montgomery G.W., Mukherjee S., Nyholt D.R., Oostra B.A., Palmer L.J., Palotie A., Penninx B.W., Perola M., Peyser P.A., Preisig M., Räikkönen K., Raitakari O.T., Realo A., Ring S.M., Ripatti S., Rivadeneira F., Rudan I., Rustichini A., Salomaa V., Sarin A.P., Schlessinger D., Scott R.J., Snieder H., St Pourcain B., Starr J.M., Sul J.H., Surakka I., Svento R., Teumer A., Tiemeier H., Tiemeier H., van Rooij F.J., Van Wagoner D.R., Vartiainen E., Viikari J., Vollenweider P., Vonk J.M., Waeber G., Weir D.R., Wichmann H.E., Widen E., Willemsen G., Wilson J.F., Wright A.F., Conley D., Davey-Smith G., Franke L., Groenen P.J., Hofman A., Johannesson M., Kardia S.L., Krueger R.F., Laibson D., Martin N.G., Meyer M.N., Posthuma D., Thurik A.R., Timpson N.J., Uitterlinden A.G., van Duijn C.M., Visscher P.M., Benjamin D.J., Cesarini D., Koellinger P.D.
Working group(s)
LifeLines Cohort Study
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
340
Number
6139
Pages
1467-1471
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Abstract
A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
Keywords
Cognition, Educational Status, Endophenotypes, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Polymorphism, Single Nucleotide
Pubmed
Web of science
Create date
26/07/2013 17:27
Last modification date
20/08/2019 17:02
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