The Aedes aegypti genome: a comparative perspective.

Details

Serval ID
serval:BIB_DE0894A70E66
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The Aedes aegypti genome: a comparative perspective.
Journal
Insect Molecular Biology
Author(s)
Waterhouse R.M., Wyder S., Zdobnov E.M.
ISSN
1365-2583 (Electronic)
ISSN-L
0962-1075
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
17
Number
1
Pages
1-8
Language
english
Abstract
The sequencing of the second mosquito genome, Aedes aegypti, in addition to Anopheles gambiae, is a major milestone that will drive molecular-level and genome-wide high-throughput studies of not only these but also other mosquito vectors of human pathogens. Here we overview the ancestry of the mosquito genes, list the major expansions of gene families that may relate to species adaptation processes, as exemplified by CYP9 cytochrome P450 genes, and discuss the conservation of chromosomal gene arrangements among the two mosquitoes and fruit fly. Many more invertebrate genomes are expected to be sequenced in the near future, including additional vectors of human pathogens (see http://www.vectorbase.org), and further comparative analyses will become increasingly refined and informative, hopefully improving our understanding of the genetic basis of phenotypical differences among these species, their vectorial capacity, and ultimately leading to the development of novel disease control strategies.
Keywords
comparative genomics, gene family, insect, mosquito, synteny, vector
Pubmed
Web of science
Create date
20/09/2017 11:26
Last modification date
03/01/2020 19:32
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