Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_DDB311A821D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.
Journal
Swiss medical weekly
Author(s)
Meyer Sauteur P.M., Moeller A., Relly C., Berger C., Plecko B., Nadal D., Giannoni E.
Working group(s)
Swiss Pediatric Surveillance Unit (SPSU)
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
146
Pages
w14222
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis.
M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases.
Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up.
The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
Keywords
Antibodies, Bacterial/cerebrospinal fluid, Child, Child, Preschool, DNA, Bacterial/cerebrospinal fluid, Female, Humans, Immunoglobulin G/cerebrospinal fluid, Immunoglobulin M/cerebrospinal fluid, Infectious Encephalitis/diagnosis, Infectious Encephalitis/epidemiology, Infectious Encephalitis/immunology, Male, Mycoplasma Infections/diagnosis, Mycoplasma Infections/epidemiology, Mycoplasma Infections/immunology, Mycoplasma pneumoniae/genetics, Mycoplasma pneumoniae/immunology, Pneumonia, Mycoplasma/diagnosis, Pneumonia, Mycoplasma/epidemiology, Pneumonia, Mycoplasma/immunology, Prospective Studies, Retrospective Studies, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
01/07/2021 10:42
Last modification date
30/10/2024 7:18
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