Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.
Details
Download: SMW_pmid-26752230.pdf (478.67 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_DDB311A821D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.
Journal
Swiss medical weekly
Working group(s)
Swiss Pediatric Surveillance Unit (SPSU)
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
146
Pages
w14222
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis.
M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases.
Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up.
The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases.
Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up.
The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
Keywords
Antibodies, Bacterial/cerebrospinal fluid, Child, Child, Preschool, DNA, Bacterial/cerebrospinal fluid, Female, Humans, Immunoglobulin G/cerebrospinal fluid, Immunoglobulin M/cerebrospinal fluid, Infectious Encephalitis/diagnosis, Infectious Encephalitis/epidemiology, Infectious Encephalitis/immunology, Male, Mycoplasma Infections/diagnosis, Mycoplasma Infections/epidemiology, Mycoplasma Infections/immunology, Mycoplasma pneumoniae/genetics, Mycoplasma pneumoniae/immunology, Pneumonia, Mycoplasma/diagnosis, Pneumonia, Mycoplasma/epidemiology, Pneumonia, Mycoplasma/immunology, Prospective Studies, Retrospective Studies, Switzerland/epidemiology
Pubmed
Web of science
Publisher's website
Open Access
Yes
Create date
01/07/2021 10:42
Last modification date
30/10/2024 7:18