Different Leishmania Species Drive Distinct Neutrophil Functions.

Details

Serval ID
serval:BIB_DD8CCEBCF19D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Different Leishmania Species Drive Distinct Neutrophil Functions.
Journal
Trends in Parasitology
Author(s)
Hurrell B.P., Regli I.B., Tacchini-Cottier F.
ISSN
1471-5007 (Electronic)
ISSN-L
1471-4922
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
32
Number
5
Pages
392-401
Language
english
Abstract
Leishmaniases are vector-borne diseases of serious public health importance. During a sand fly blood meal, Leishmania parasites are deposited in the host dermis where neutrophils are rapidly recruited. Neutrophils are the first line of defense and can kill pathogens by an array of mechanisms. They can also form web-like structures called neutrophil extracellular traps (NETs) that can trap and/or kill microbes. The function of neutrophils in leishmaniasis was reported to be either beneficial by contributing to parasite killing or detrimental by impairing immune response development and control of parasite load. Here we review recent data showing that different Leishmania species elicit distinct neutrophil functions thereby influencing disease outcomes. Emerging evidence suggests that neutrophils should be considered important modulators of leishmaniasis.
Pubmed
Web of science
Create date
15/03/2016 20:45
Last modification date
20/08/2019 17:02
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