Treatment options in the management of status epilepticus.

Details

Ressource 1Download: serval:BIB_DD8B53517150.P001 (503.47 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_DD8B53517150
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Treatment options in the management of status epilepticus.
Journal
Current treatment options in neurology
Author(s)
Rossetti A.O.
ISSN
1534-3138 (Electronic)
ISSN-L
1092-8480
Publication state
Published
Issued date
03/2010
Peer-reviewed
Oui
Volume
12
Number
2
Pages
100-112
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Status epilepticus treatment involves the use of several pharmacologic compounds, which are conceptually divided into three successive and additional lines of action. Because of their rapid onset of action, benzodiazepines represent the first approach; these are followed by classic antiepileptic drugs that are administered intravenously. In refractory episodes, pharmacologic coma induction with an appropriate anesthetic is advocated. Apart from first-line compounds, the level of evidence for medications used in status epilepticus is extremely limited. It is important to specifically address etiology in order to maximize the impact of the antiepileptic therapy. Fine-tuning of the treatment strategy, mainly regarding the choice of whether to induce coma, should be approached by balancing the benefits of rapid control of the status epilepticus with the risks of adverse effects. Although each status epilepticus episode should be treated as rapidly as possible, it appears advisable to reserve coma induction for those forms, such as generalized convulsive status, that have been shown to present a consistent risk of neurologic sequelae.

Keywords
Refractory Status Epilepticus, Nonconvulsive Status Epilepticus, Acute Repetitive Seizures, Intravenous Valproate, Pharmacokinetics, Propofol, Levetiracetam, Phenytoin, Midazolam, Infusion, Clinical Neurology
Pubmed
Web of science
Open Access
Yes
Create date
18/05/2010 15:26
Last modification date
01/10/2019 6:19
Usage data