Magnetic resonance imaging in clinical trials

Details

Serval ID
serval:BIB_DD895FD6177B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Magnetic resonance imaging in clinical trials
Journal
Curr Opin Neurol
Author(s)
Ciumas C., Montavont A., Ryvlin P.
ISSN
1350-7540 (Print)
ISSN-L
1350-7540
Publication state
Published
Issued date
08/2008
Volume
21
Number
4
Pages
431-6
Language
english
Notes
Ciumas, Carolina
Montavont, Alexandra
Ryvlin, Philippe
eng
Review
England
Curr Opin Neurol. 2008 Aug;21(4):431-6. doi: 10.1097/WCO.0b013e3283056a3c.
Abstract
PURPOSE OF REVIEW: The aim of this article is to review the latest clinical trials in neurological diseases where magnetic resonance imaging was used to assess treatment outcome. RECENT FINDINGS: The unique sensitivity of magnetic resonance imaging for detecting disorders in the brain has made it an attractive noninvasive tool for assessing treatment efficacy in several diseases. Volumetric and functional magnetic resonance imaging have proved to represent robust biomarkers for the evaluation of anti-Alzheimer treatments, and have demonstrated a significant impact of cholinesterase inhibitors. The optimization of thrombolytic therapy in acute ischemic stroke has concentrated on the quantification of the ischemic penumbra, using perfusion-weighted and diffusion-weighted imaging. Standard assessment of T2 or fluid-attenuated inversion recovery lesion load remains the method of choice to evaluate new therapeutic strategy in multiple sclerosis. Other nonconventional quantitative magnetic resonance imaging techniques such as magnetic resonance volumetry, magnetization transfer imaging, diffusion-weighted imaging, or magnetic resonance spectroscopy are increasingly used in the field. SUMMARY: Magnetic resonance imaging has become a major surrogate marker of treatment response in clinical trials of neurological disorders, offering the possibility to reduce the required sample size or to shorten the duration of the trial.
Keywords
Alzheimer Disease/pathology/*therapy, Clinical Trials as Topic/*methods, Humans, Magnetic Resonance Imaging/*methods, Multiple Sclerosis/pathology/*therapy, Stroke/pathology/*therapy, Treatment Outcome
Pubmed
Create date
29/11/2018 12:36
Last modification date
20/08/2019 16:02
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