Switzerland is a multicultural country, with 4 official languages. Its health system is quite uniform in terms of general regulation and teaching of physicians. However, differences are frequently observed between the linguistic regions, even when considering other possibly confounding factors. Data from 1065 general practitioners (GPs) on continuity and coordination of care from the International Health Policy Survey by the Commonwealth Fund, are analysed in this research. We described 42 selected questions and searched for differences between the French-speaking and German-speaking areas. Of these questions, 17 were selected for deeper analysis to observe association with language while considering socio-demographic factors (age, sex, rurality and type of practice). The results show significant differences in more than half of the 42 first selected questions between linguistic areas, favouring continuity and use of computerized system in the German-speaking region, and favouring better coordination in the French-speaking region. When applying the multivariate analysis on the 17 selected questions, it showed consistency with the first results even after considering socio-demographic factors. These differences can be due to a different culture between the language areas, but we found other factors that could possibly explain some of the variation. These factors include propharmacy that is only present in some German-speaking administrative divisions (cantons), managed care that is more present in the German-speaking area, patient experience, attitude of GPs towards prevention and some aspects of integrated care. Linguistic regions’ variation is a subject that needs deeper investigation, and might be a socio-demographic factor to include in further studies in Switzerland.