A Blueprint for HIV Vaccine Discovery.
Details
Serval ID
serval:BIB_DD66D075AE23
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Blueprint for HIV Vaccine Discovery.
Journal
Cell host & microbe
ISSN
1934-6069 (Electronic)
ISSN-L
1931-3128
Publication state
Published
Issued date
18/10/2012
Peer-reviewed
Oui
Volume
12
Number
4
Pages
396-407
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.
Keywords
AIDS Vaccines/immunology, Allergy and Immunology/trends, Animals, Antibodies, Neutralizing/blood, Antibodies, Neutralizing/immunology, Antibodies, Viral/blood, Antibodies, Viral/immunology, B-Lymphocytes/immunology, Clinical Trials as Topic, Disease Models, Animal, HIV Infections/prevention & control, Humans, T-Lymphocytes/immunology
Pubmed
Web of science
Publisher's website
Open Access
Yes
Create date
09/05/2023 12:59
Last modification date
29/11/2024 17:12