The microbiome in respiratory medicine: current challenges and future perspectives.

Details

Serval ID
serval:BIB_DD48B497C4CB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The microbiome in respiratory medicine: current challenges and future perspectives.
Journal
The European respiratory journal
Author(s)
Faner R., Sibila O., Agustí A., Bernasconi E., Chalmers J.D., Huffnagle G.B., Manichanh C., Molyneaux P.L., Paredes R., Pérez Brocal V., Ponomarenko J., Sethi S., Dorca J., Monsó E.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
49
Number
4
Pages
1602086
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The healthy lung has previously been considered to be a sterile organ because standard microbiological culture techniques consistently yield negative results. However, culture-independent techniques report that large numbers of microorganisms coexist in the lung. There are many unknown aspects in the field, but available reports show that the lower respiratory tract microbiota: 1) is similar in healthy subjects to the oropharyngeal microbiota and dominated by members of the Firmicutes, Bacteroidetes and Proteobacteria phyla; 2) shows changes in smokers and well-defined differences in chronic respiratory diseases, although the temporal and spatial kinetics of these changes are only partially known; and 3) shows relatively abundant non-cultivable bacteria in chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis and bronchiectasis, with specific patterns for each disease. In all of these diseases, a loss of diversity, paralleled by an over-representation of Proteobacteria (dysbiosis), has been related to disease severity and exacerbations. However, it is unknown whether dysbiosis is a cause or a consequence of the damage to bronchoalveolar surfaces.Finally, little is known about bacterial functionality and the interactions between viruses, fungi and bacteria. It is expected that future research in bacterial gene expressions, metagenomics longitudinal analysis and host-microbiome animal models will help to move towards targeted microbiome interventions in respiratory diseases.

Keywords
Animals, Bacteroidetes/classification, Bronchiectasis/microbiology, Cystic Fibrosis/microbiology, Dysbiosis, Host-Pathogen Interactions, Humans, Idiopathic Interstitial Pneumonias/microbiology, Lung/microbiology, Mice, Microbiota, Proteobacteria/classification, Pulmonary Disease, Chronic Obstructive/microbiology, Pulmonary Medicine, Risk Factors, Terminology as Topic
Pubmed
Web of science
Open Access
Yes
Create date
28/04/2017 9:00
Last modification date
20/08/2019 16:02
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