Transvaginal administration of progesterone

Details

Serval ID
serval:BIB_DD2FD826568C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transvaginal administration of progesterone
Journal
Obstetrics and Gynecology
Author(s)
Fanchin  R., De Ziegler  D., Bergeron  C., Righini  C., Torrisi  C., Frydman  R.
ISSN
0029-7844
Publication state
Published
Issued date
09/1997
Peer-reviewed
Oui
Volume
90
Number
3
Pages
396-401
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Sep
Abstract
OBJECTIVE: To examine the endometrial effects of three different doses of progesterone administered vaginally. METHODS: Forty women 25-41 years old deprived of ovarian function received estradiol (E2) for 28 days. From days 15 to 27, a new mucus-like vaginal gel of progesterone was administered every other day, randomly, dosed at 45 mg (group A, n = 14), 90 mg (group B, n = 13), or 180 mg (group C, n = 13). Plasma gonadotropins, estrone, E2, and progesterone were measured. An endometrial biopsy was performed on day 20 (n = 20) or 24 (n = 20) for endometrial dating and for estrogen and progesterone receptor determinations. RESULTS: Plasma estrogen levels were in the menstrual cycle range. Mean progesterone levels were lower in group A (2.4 +/- 0.2 ng/mL) than in group B (3.6 +/- 0.2 ng/mL) or C (3.4 +/- 0.4 ng/mL) (P < .005). Plasma FSH and LH decreased significantly during progesterone treatment. In all groups, we observed secretory transformation in the glands (day 20) and stroma (day 24) and the distribution of estrogen and progesterone receptors seen in normal menstrual cycles. CONCLUSION: Transvaginal administration of progesterone induced normal secretory transformation of the endometrium despite low plasma levels, suggesting a direct transit into the uterus or "first uterine pass effect."
Keywords
Administration, Intravaginal Adult Endometrium/chemistry/*drug effects/metabolism/pathology Female Follicle Stimulating Hormone/blood Gels Humans Luteinizing Hormone/blood Progesterone/*administration & dosage/analysis/blood Receptors, Estrogen/analysis Time Factors
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 16:01
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