PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex.

Details

Serval ID
serval:BIB_DD20E8636D5A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Palmieri M., Brilhante M., Masseron A., Perreten V., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
27/01/2020
Peer-reviewed
Oui
Volume
64
Number
2
Pages
e01700-19
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β-lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola The bla <sub>PFM-1</sub> gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.
Keywords
Amino Acid Sequence, Anti-Bacterial Agents/metabolism, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/chemistry, Bacterial Proteins/genetics, Carbapenems/metabolism, Carbapenems/pharmacology, Drug Resistance, Bacterial/genetics, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/metabolism, Kinetics, Microbial Sensitivity Tests, Pseudomonas/drug effects, Pseudomonas/enzymology, Pseudomonas fluorescens/drug effects, Pseudomonas fluorescens/enzymology, beta-Lactamases/biosynthesis, beta-Lactamases/chemistry, beta-Lactamases/classification, beta-Lactamases/genetics, PFM-1, Pseudomonas fluorescens, metallo-beta-lactamase
Pubmed
Web of science
Open Access
Yes
Create date
05/12/2020 16:23
Last modification date
10/02/2024 7:15
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