Breast metastasis as the first clinical manifestation of ileal neuroendocrine tumor. A challenging diagnosis with relevant clinical implications.

Details

Serval ID
serval:BIB_DD1695636E64
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Breast metastasis as the first clinical manifestation of ileal neuroendocrine tumor. A challenging diagnosis with relevant clinical implications.
Journal
Endocrine Pathology
Author(s)
La Rosa S., Casnedi S., Maragliano R., Goyault G., Weber J.C., Louis B., Schlund E., Sessa F.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
26
Number
2
Pages
145-151
Language
english
Notes
Publication types: Case Reports ; Journal Article ; ReviewPublication Status: ppublish
Abstract
Ileal neuroendocrine tumors are slow-growing grade 1 or, more rarely, grade 2 neuroendocrine tumors which, however, are frequently metastatic to regional lymph nodes and the liver. A few cases of ileal neuroendocrine tumors that are metastatic to the breast have also been reported in the medical literature. The knowledge of this uncommon clinical presentation is of great importance because it needs to be differentiated from primary breast carcinomas with neuroendocrine features, which represent completely different entities with a different therapeutic approach. The diagnosis of a breast metastasis from an ileal neuroendocrine tumor and its distinction from a well-differentiated primary neuroendocrine tumor of the breast is a challenging task for clinicians and pathologists. This workup is particularly difficult when the breast lesion is the first sign of malignancy. In the present paper, we describe the clinicopathological features of an ileal neuroendocrine tumor first presenting with a breast metastasis in a 50-year-old woman and we discuss the key diagnostic features for the differential diagnosis with primary well-differentiated neuroendocrine tumor of the breast. Moreover, we have reviewed the medical literature to give the reader a comprehensive overview on this topic.
Keywords
Breast Neoplasms/diagnosis, Breast Neoplasms/secondary, Diagnosis, Differential, Female, Humans, Ileal Neoplasms/pathology, Middle Aged, Neuroendocrine Tumors/pathology
Pubmed
Web of science
Create date
06/09/2016 12:52
Last modification date
20/08/2019 17:01
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