Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

Details

Serval ID
serval:BIB_DD10436D47E8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Journal
Nature
Author(s)
Lande R., Gregorio J., Facchinetti V., Chatterjee B., Wang Y.H., Homey B., Cao W., Wang Y.H., Su B., Nestle F.O., Zal T., Mellman I., Schröder J.M., Liu Y.J., Gilliet M.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
2007
Volume
449
Number
7162
Pages
564-569
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrobial peptide LL37 (also known as CAMP) as the key factor that mediates pDC activation in psoriasis, a common autoimmune disease of the skin. LL37 converts inert self-DNA into a potent trigger of interferon production by binding the DNA to form aggregated and condensed structures that are delivered to and retained within early endocytic compartments in pDCs to trigger Toll-like receptor 9. Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Keywords
Antimicrobial Cationic Peptides/metabolism, Autoantigens/immunology, Autoantigens/metabolism, Autoimmune Diseases/immunology, Autoimmune Diseases/metabolism, Autoimmunity, Cathelicidins, DNA/immunology, DNA/metabolism, Dendritic Cells/immunology, Dendritic Cells/metabolism, Endocytosis, Endosomes/immunology, Endosomes/metabolism, Humans, Psoriasis/immunology, Psoriasis/metabolism, Toll-Like Receptor 9/immunology, Toll-Like Receptor 9/metabolism
Pubmed
Web of science
Create date
23/03/2012 11:58
Last modification date
20/08/2019 16:01
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