Bronchial provocation with cat allergen: long-term outcome of the late allergic reaction and the individual IgE CRIE pattern

Details

Serval ID
serval:BIB_DD06DC9EF980
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bronchial provocation with cat allergen: long-term outcome of the late allergic reaction and the individual IgE CRIE pattern
Journal
Journal of Investigational Allergology and Clinical Immunology
Author(s)
Wasserfallen  J. B., Aubert  V., Mosimann  B., Leuenberger  P.
ISSN
1018-9068 (Print)
Publication state
Published
Issued date
06/1995
Volume
5
Number
3
Pages
134-41
Notes
Journal Article --- Old month value: May-Jun
Abstract
In bronchial provocation tests with allergen, about 50% of the patients experienced a late allergic reaction (LAR), which has been associated with a specific IgE pattern as determined by crossed radioimmunoelectrophoresis (CRIE). Long-term outcome of this LAR is still unknown. Six patients allergic to cat, with documented LAR and specific IgE CRIE patterns were rechallenged in the same conditions after a mean interval of 2.5 years. Forced expiratory volume in one second (FEV1) and resistance results of the bronchial provocation tests (BPT) were compared, as well as specific IgE level and IgE CRIE patterns. All six patients were still suffering from asthma when exposed to a cat, although they were not being treated for asthma. Three patients (50%) had lost their LAR without specific treatment. They were older, with a longer history of asthma, but presented a very similar early allergic reaction to similar allergen doses. The other 3 were more reactive to the allergen but presented similar LAR after a slightly worse early allergic reaction (EAR). Specific IgE levels had decreased and the IgE CRIE pattern showed a diminished intensity of staining in the three patients who had lost their LAR, as opposed to the other three. These data suggest that asthmatic patients can lose their LAR over time without treatment. The occurrence of a LAR seems to be associated with a specific IgE CRIE pattern and IgE level. Further analysis of the individual antigen fractions might help to understand the mechanism of allergic reactions.
Keywords
Adult Allergens/*immunology Animals Asthma/*immunology/physiopathology *Bronchial Provocation Tests Cats/immunology Female Forced Expiratory Volume/immunology Humans Immunoelectrophoresis, Two-Dimensional/methods Immunoglobulin E/*blood Male Middle Aged
Pubmed
Web of science
Create date
25/01/2008 14:12
Last modification date
20/08/2019 16:01
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