Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_DCBA17B192C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis.
Journal
Frontiers in immunology
Author(s)
Haghayegh Jahromi N., Marchetti L., Moalli F., Duc D., Basso C., Tardent H., Kaba E., Deutsch U., Pot C., Sallusto F., Stein J.V., Engelhardt B.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
10
Pages
3056
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), where they induce neuroinflammation. Here, we explored the role of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in the activation of naïve myelin-specific T cells and in the subsequent migration of differentiated encephalitogenic Th1 and Th17 cells across the BBB in vitro and in vivo. While on antigen-presenting cells ICAM-1, but not ICAM-2 was required for the activation of naïve CD4 <sup>+</sup> T cells, endothelial ICAM-1 and ICAM-2 mediated both Th1 and Th17 cell migration across the BBB. ICAM-1/-2-deficient mice developed ameliorated typical and atypical EAE transferred by encephalitogenic Th1 and Th17 cells, respectively. Our study underscores important yet cell-specific contributions for ICAM-1 and ICAM-2 in EAE pathogenesis.
Keywords
Cancer Research, Oncology, Radiology Nuclear Medicine and imaging, ICAM-1, ICAM-2, T cell activation, Th1 cells, Th17 cells, blood-brain barrier, dendritic cells, experimental autoimmune encephalomyelitis
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2020 11:10
Last modification date
30/04/2021 6:37
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