CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_DCA4A5411D48
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.
Journal
Virchows Archiv
Author(s)
Monteiro I., Missiaglia E., Sciarra A., Santos J.V., Bouilly J., Romero P., Sempoux C., de Leval L.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
07/2021
Peer-reviewed
Oui
Volume
479
Number
1
Pages
209-214
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
CD73 converts AMP to adenosine, an immunosuppressive metabolite that promotes tumorigenesis. This study presents a systematic evaluation of CD73 expression in benign, hyperplastic, and neoplastic thyroid. CD73 expression was assessed by immunohistochemistry in 142 thyroid samples. CD73 was expressed in normal thyroid (3/6) and goiter (5/6), with an apical pattern and mild intensity. Apical and mild CD73 expression was also present in oncocytic cell adenomas/carcinomas (9/10; 5/8) and in follicular adenomas/carcinomas (12/18; 23/27). In contrast, papillary thyroid carcinomas featured extensive and intense CD73 staining (49/50) (vs. normal thyroid/goiter, p < 0.001). Seven of nine anaplastic carcinomas were CD73-positive with heterogeneous extensiveness of staining. Medullary and poorly differentiated carcinomas were mostly CD73-negative (1/6; 2/2). These results were corroborated by NT5E mRNA profiling. Papillary carcinomas feature enhanced CD73 protein and mRNA expression with distinct and intense staining, more pronounced in the invasive fronts of the tumors.
Keywords
CD73, Immunohistochemistry, Papillary thyroid carcinoma, Thyroid adenoma, Thyroid carcinoma
Pubmed
Web of science
Open Access
Yes
Create date
25/05/2021 9:26
Last modification date
31/07/2021 6:34
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