Prevalence of Hypertensive Phenotypes After Preeclampsia: A Prospective Cohort Study.

Details

Serval ID
serval:BIB_DC9EEF1BC857
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prevalence of Hypertensive Phenotypes After Preeclampsia: A Prospective Cohort Study.
Journal
Hypertension
Author(s)
Ditisheim A., Wuerzner G., Ponte B., Vial Y., Irion O., Burnier M., Boulvain M., Pechère-Bertschi A.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
71
Number
1
Pages
103-109
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Preeclampsia is associated with increased cardiovascular and renal risk. The aim of this prospective cohort study was to characterize the early postpartum blood pressure (BP) profile after preeclampsia. We enrolled 115 women with preeclampsia and 41 women with a normal pregnancy in a prospective cohort study. At 6 to 12 week postpartum, we assessed the prevalence of different hypertensive phenotypes using 24-hour ambulatory BP monitoring (ABPM), as well as the risk of salt sensitivity and the variability of BP derived from ABPM parameters. Among patients with preeclampsia, 57.4% were still hypertensive at the office. Daytime ABP was significantly higher in the preeclampsia group (118.9±15.0/83.2±10.4 mm Hg) than in controls (104.8±7.9/71.6±5.3 mm Hg; P<0.01). Differences between groups were similar for nocturnal BP values. Fifty percent of preeclampsia women remained hypertensive on ABPM in the postpartum, of whom 24.3% were still under antihypertensive treatment; 17.9% displayed a white-coat hypertension and 11.6% had masked hypertension. In controls, 2.8% had white-coat hypertension; none had masked hypertension or needed hypertensive treatment. The prevalence of nondippers was similar 59.8% in the preeclampsia group versus 51.4% in controls. High-risk class of salt sensitivity of BP was increased in preeclampsia women (48.6%) compared with controls (17.1%); P<0.01. In conclusion, ABPM 6 to 12 weeks after delivery reveals a high rate of sustained ambulatory, nocturnal, and masked hypertension after preeclampsia. This finding may help identify women who should be included in a postpartum cardiovascular risk management program.
URL: https://www.clinicaltrials.gov. Unique identifier: NCT01095939.

Keywords
Adult, Antihypertensive Agents/therapeutic use, Blood Pressure/physiology, Blood Pressure Monitoring, Ambulatory/methods, Cohort Studies, Female, Humans, Hypertension/classification, Hypertension/diagnosis, Hypertension/epidemiology, Hypertension/genetics, Phenotype, Postpartum Period/physiology, Pre-Eclampsia/epidemiology, Pregnancy, Prevalence, Prospective Studies, Risk Factors, Switzerland/epidemiology, blood pressure, masked hypertension, postpartum period, preeclampsia, pregnancy
Pubmed
Web of science
Open Access
Yes
Create date
16/11/2017 22:22
Last modification date
20/08/2019 17:01
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