Visual cortex in Alzheimer's disease: occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks.

Details

Serval ID
serval:BIB_DC78C878F857
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Visual cortex in Alzheimer's disease: occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks.
Journal
Neurobiology of Aging
Author(s)
Leuba G., Kraftsik R.
ISSN
0197-4580 (Print)
ISSN-L
0197-4580
Publication state
Published
Issued date
1994
Volume
15
Number
1
Pages
29-43
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Visual areas 17 and 18 were studied with morphometric methods for numbers of neurons, glia, senile plaques (SP), and neurofibrillary tangles (NFT) in 13 cases of Alzheimer's disease (AD) as compared to 11 controls. In AD cases, the mean neuronal density was significantly decreased by about 30% in both areas 17 and 18, while the glial density was increased significantly only in area 17. The volume of area 17 was unchanged in AD cases but its total number of neurons was decreased by 33% and its total number of glia increased by 45% compared to controls. In AD the number of SP was similar in areas 17 and 18, while that of NFT was significantly higher in area 18. The number of neurons with NFT was only 2% in area 17 and about 10% in area 18. The discrepancy between the loss of neurons and the amount of NFT suggests that neuronal loss can occur without passing through NFT degeneration. The deposition of SP was correlated with glial proliferation, but not with neuronal loss or neurofibrillary degeneration.
Keywords
Aged, Aged, 80 and over, Alzheimer Disease/pathology, Cell Death/physiology, Cell Division/physiology, Female, Humans, Male, Middle Aged, Nerve Degeneration/physiology, Neurofibrillary Tangles/pathology, Neuroglia/physiology, Neurons/physiology, Organ Size/physiology, Visual Cortex/pathology
Pubmed
Web of science
Create date
03/09/2011 20:03
Last modification date
20/08/2019 16:01
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