Cell specificity of granzyme gene expression
Details
Serval ID
serval:BIB_DC60017F7901
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cell specificity of granzyme gene expression
Journal
Journal of Immunology
ISSN
0022-1767 (Print)
Publication state
Published
Issued date
11/1990
Volume
145
Number
9
Pages
3111-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 1
Research Support, Non-U.S. Gov't --- Old month value: Nov 1
Abstract
Granzymes are serine proteases present in secretory granules of cytolytic T lymphocyte lines. We have studied the expression of the granzyme family (granzyme A, B, C, D, E, F, and G) in different lymphoid cell populations and cell lines as well as in nonlymphoid cells and tissues. Our data show that with few exceptions expression of granzyme genes is restricted to T cells and their thymic precursors. In mature T cells granzymes are expressed only upon activation. The same is true for thymocytes, with the exception of grazyme A that is expressed also in non-stimulated cells. In T cells and thymocytes the distribution of mRNAs coding for different granzymes depends on the subpopulation tested and the activation protocol. Highly cytolytic PEL express granzymes A and B but none of the other granzymes.
Keywords
Animals
Blotting, Northern
Cell Line
Cloning, Molecular
DNA Probes
Gene Expression
Granzymes
Lymphocytes/*physiology
Lymphoid Tissue/physiology
Mice
Mice, Inbred Strains
RNA, Messenger/genetics
Ribonucleases
Serine Endopeptidases/*genetics
T-Lymphocyte Subsets/physiology
Tissue Distribution
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 16:01