Local recurrence rate in patients with colorectal cancer liver metastasis after wedge resection or percutaneous radiofrequency ablation.

Details

Serval ID
serval:BIB_DC23DE6832BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Local recurrence rate in patients with colorectal cancer liver metastasis after wedge resection or percutaneous radiofrequency ablation.
Journal
International journal of hyperthermia
Author(s)
Vietti Violi N., Duran R., Demartines N., Sempoux C., Guiu B., Bize P.E., Sala N., Halkic N., Knebel J.F., Denys A.
ISSN
1464-5157 (Electronic)
ISSN-L
0265-6736
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
34
Number
7
Pages
1020-1028
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To compare local recurrence (LR) rate in patients with colorectal cancer liver metastasis (CRCLM) after surgical wedge resection (WR) or radiofrequency ablation (RFA) and to investigate predictive factors of LR.
This single-centre, retrospective, institutional review board-approved study including 43 consecutive patients with 121 metastases treated by WR and 60 patients with 110 metastases treated by RFA between 2007 and 2014 with 23 and 18.5 months of follow-up, respectively. Demographics and tumour characteristics were compared using the unpaired t-test and chi-square test. Predictive factors for LR (lesion size, depth, relation to hepatic vessels, intervention, margin status) were investigated in uni- and multivariate analyses.
Patient and CRCLM characteristics were similar in both groups. Mean lesion size and depth in the WR and RFA groups were 18 mm and 15 mm (p = 0.03), and 19 mm and 26 mm (p < 0.001), respectively. LR showed a trend towards difference in favour of RFA (19% and 10% in the WR and RFA groups, respectively, p = 0.06). Positive margins and lesion depth were predictive factors of LR in the WR group (p = 0.03 and p = 0.02, respectively, on uni- and multivariable analyses). Lesion depth and proximity to a vein increased the risk of positive margins on pathology after WR (p = 0.04 and p < 0.001, respectively). Our analysis did not identify any predictive factors of LR following RFA.
Our study showed a trend towards a lower LR rate with RFA compared to WR. Lesions located deep in the liver and/or close to large vessels are at high risk of LR following WR, while curative treatment can be obtained with RFA.
Keywords
Adult, Aged, Colorectal Neoplasms/pathology, Colorectal Neoplasms/radiotherapy, Female, Humans, Liver Neoplasms/pathology, Liver Neoplasms/secondary, Liver Neoplasms/surgery, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local, Radiofrequency Ablation/methods, Retrospective Studies, Wedge resection, colorectal cancer, liver metastasis, local recurrence, radiofrequency ablation
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2018 10:33
Last modification date
06/05/2020 16:55
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