Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

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Version: author
Serval ID
serval:BIB_DBEEF95D2F27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Journal
Nature Genetics
Author(s)
Wain L.V., Verwoert G.C., O'Reilly P.F., Shi G., Johnson T., Johnson A.D., Bochud M., Rice K.M., Henneman P., Smith A.V., Ehret G.B., Amin N., Larson M.G., Mooser V., Hadley D., Dörr M., Bis J.C., Aspelund T., Esko T., Janssens A.C., Zhao J.H., Heath S., Laan M., Fu J., Pistis G., Luan J., Arora P., Lucas G., Pirastu N., Pichler I., Jackson A.U., Webster R.J., Zhang F., Peden J.F., Schmidt H., Tanaka T., Campbell H., Igl W., Milaneschi Y., Hottenga J.J., Vitart V., Chasman D.I., Trompet S., Bragg-Gresham J.L., Alizadeh B.Z., Chambers J.C., Guo X., Lehtimäki T., Kühnel B., Lopez L.M., Pola?ek O. , Boban M., Nelson C.P., Morrison A.C., Pihur V., Ganesh S.K., Hofman A., Kundu S., Mattace-Raso F.U., Rivadeneira F., Sijbrands E.J., Uitterlinden A.G., Hwang S.J., Vasan R.S., Wang T.J., Bergmann S., Vollenweider P., Waeber G., Laitinen J., Pouta A., Zitting P., McArdle W.L., Kroemer H.K., Völker U., Völzke H., Glazer N.L., Taylor K.D., Harris T.B., Alavere H., Haller T., Keis A., Tammesoo M.L., Aulchenko Y., Barroso I., Khaw K.T., Galan P., Hercberg S., Lathrop M., Eyheramendy S., Org E., Sõber S., Lu X., Nolte I.M., Penninx B.W., Corre T., Masciullo C., Sala C., Groop L., Voight B.F., Melander O., O'Donnell C.J., Salomaa V., d'Adamo A.P., Fabretto A., Faletra F., Ulivi S., Del Greco M F., Facheris M., Collins F.S., Bergman R.N., Beilby J.P., Hung J., Musk A.W., Mangino M., Shin S.Y., Soranzo N., Watkins H., Goel A., Hamsten A., Gider P., Loitfelder M., Zeginigg M., Hernandez D., Najjar S.S., Navarro P., Wild S.H., Corsi A.M., Singleton A., de Geus E.J., Willemsen G., Parker A.N., Rose L.M., Buckley B., Stott D., Orru M., Uda M., van der Klauw M.M., Zhang W., Li X., Scott J., Chen Y.D., Burke G.L., Kähönen M., Viikari J., Döring A., Meitinger T., Davies G., Starr J.M., Emilsson V., Plump A., Lindeman J.H., Hoen P.A., König I.R., Felix J.F., Clarke R., Hopewell J.C., Ongen H., Breteler M., Debette S., Destefano A.L., Fornage M., Mitchell G.F., Smith N.L., Holm H., Stefansson K., Thorleifsson G., Thorsteinsdottir U., Samani N.J., Preuss M., Rudan I., Hayward C., Deary I.J., Wichmann H.E., Raitakari O.T., Palmas W., Kooner J.S., Stolk R.P., Jukema J.W., Wright A.F., Boomsma D.I., Bandinelli S., Gyllensten U.B., Wilson J.F., Ferrucci L., Schmidt R., Farrall M., Spector T.D., Palmer L.J., Tuomilehto J., Pfeufer A., Gasparini P., Siscovick D., Altshuler D., Loos R.J., Toniolo D., Snieder H., Gieger C., Meneton P., Wareham N.J., Oostra B.A., Metspalu A., Launer L., Rettig R., Strachan D.P., Beckmann J.S., Witteman J.C., Erdmann J., van Dijk K.W., Boerwinkle E., Boehnke M., Ridker P.M., Jarvelin M.R., Chakravarti A., Abecasis G.R., Gudnason V., Newton-Cheh C., Levy D., Munroe P.B., Psaty B.M., Caulfield M.J., Rao D.C., Tobin M.D., Elliott P., van Duijn C.M., CardioGram 
Working group(s)
LifeLines Cohort Study, EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen consortium, CKDGen consortium, Cardiogenics consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
43
Number
10
Pages
1005-1011
Language
english
Abstract
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Keywords
Arteries/metabolism, Blood Pressure/genetics, Case-Control Studies, Follow-Up Studies, Genetic Loci, Genome-Wide Association Study, Humans, Hypertension/genetics, Linkage Disequilibrium, Polymorphism, Single Nucleotide
Pubmed
Web of science
Create date
13/09/2011 16:33
Last modification date
20/08/2019 17:00
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