Assessment of Waldeyer's ring in pediatric and adolescent Hodgkin lymphoma patients-Importance of multimodality imaging: Results from the EuroNet-PHL-C1 trial.

Details

Serval ID
serval:BIB_DBD0CBB22042
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of Waldeyer's ring in pediatric and adolescent Hodgkin lymphoma patients-Importance of multimodality imaging: Results from the EuroNet-PHL-C1 trial.
Journal
Pediatric blood & cancer
Author(s)
Kurch L., Mauz-Körholz C., Fosså A., Georgi T.W., Kluge R., Bartelt J.M., Kunze C., Wohlgemuth W.A., Pelz T., Vordermark D., Plößl S., Hasenclever D., Sabri O., Landman-Parker J., Wallace W.H., Karlen J., Fernández-Teijeiro A., Cepelova M., Klekawka T., Løndalen A.M., Steiner D., Krombach G., Attarbaschi A., Hoffmann M., Ceppi F., Pears J., Hraskova A., Uyttebroeck A., Beishuizen A., Dieckmann K., Leblanc T., Daw S., Körholz D., Stoevesandt D.
ISSN
1545-5017 (Electronic)
ISSN-L
1545-5009
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
68
Number
4
Pages
e28903
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In the EuroNet Pediatric Hodgkin Lymphoma (EuroNet-PHL) trials, decision on Waldeyer's ring (WR) involvement is usually based on clinical assessment, that is, physical examination and/or nasopharyngoscopy. However, clinical assessment only evaluates mucosal surface and is prone to interobserver variability. Modern cross-sectional imaging technology may provide valuable information beyond mucosal surface, which may lead to a more accurate WR staging.
The EuroNet-PHL-C1 trial recruited 2102 patients, of which 1752 underwent central review including reference reading of their cross-sectional imaging data. In 14 of 1752 patients, WR was considered involved according to clinical assessment. In these 14 patients, the WR was re-assessed by applying an imaging-based algorithm considering information from <sup>18</sup> F-fluorodeoxyglucose positron emission tomography, contrast-enhanced computed tomography, and/or magnetic resonance imaging. For verification purposes, the imaging-based algorithm was applied to 100 consecutive patients whose WR was inconspicuous on clinical assessment.
The imaging-based algorithm confirmed WR involvement only in four of the 14 patients. Of the remaining 10 patients, four had retropharyngeal lymph node involvement and six an inconspicuous WR. Applying the imaging-based algorithm to 100 consecutive patients with physiological appearance of their WR on clinical assessment, absence of WR involvement could be confirmed in 99. However, suspicion of WR involvement was raised in one patient.
The imaging-based algorithm was feasible and easily applicable at initial staging of young patients with Hodgkin lymphoma. It increased the accuracy of WR staging, which may contribute to a more individualized treatment in the future.
Keywords
18F-FDG-PET, CT, ENT investigation, MRI, Waldeyer's ring, multimodality imaging, pediatric Hodgkin lymphoma, staging
Pubmed
Web of science
Open Access
Yes
Create date
23/02/2021 8:33
Last modification date
05/05/2021 5:36
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