Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma: a prospective study.
Details
Serval ID
serval:BIB_DB9CAD964176
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma: a prospective study.
Journal
Cancer
ISSN
0008-543X[print], 0008-543X[linking]
Publication state
Published
Issued date
2004
Volume
100
Number
5
Pages
935-941
Language
english
Abstract
BACKGROUND: Previous reports have shown that regional lymph node involvement in patients with early-stage breast carcinoma can be evaluated by resection of axillary sentinel lymph nodes (ASLN). Axillary lymphadenectomy may be unnecessary in the absence of ASLN involvement. In the current study, the authors compared the results of ASLN resection in patients with lobular invasive carcinoma (LIC) with the results from patients with ductal invasive carcinoma (DIC) in terms of detection rates and false-negative rates. METHODS: For ASLN detection, technetium 99m sulfur-colloid and patent blue were injected around the tumor. Each patient underwent both ASLN resection and complete axillary lymphadenectomy. Detection rates and false-negative rates were evaluated in patients with LIC and in patients with DIC. RESULTS: Two hundred forty-three patients with invasive, early-stage breast carcinoma were enrolled in the study (208 patients with DIC and 35 patients with LIC). The median patient age, pathologic tumor size, hormone receptor status, and rates of involved lymph nodes were equivalent for both groups. ASLN detection and false-negative rates did not differ for patients with LIC and patients with DIC. CONCLUSIONS: The ASLN detection rate was not dependent on the pathologic type of invasive carcinoma. Pathologic examination of ASLN in patients with LIC and in patients with DIC predicted axillary lymph node status with the same predictive value in terms of lymph node metastasis. For patients with LIC, ASLN examination overestimated the rate of micrometastasis as diagnosed by immunohistochemical techniques. These results will require confirmation in larger studies.
Keywords
Aged, Axilla, Biopsy, Needle, Breast Neoplasms/pathology, Carcinoma, Ductal, Carcinoma, Ductal, Breast/pathology, Carcinoma, Ductal, Breast/secondary, Carcinoma, Lobular/pathology, Carcinoma, Lobular/secondary, Chi-Square Distribution, Female, Humans, Immunohistochemistry, Lymph Node Excision/methods, Lymph Nodes/pathology, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Probability, Prognosis, Prospective Studies, Risk Assessment, Sensitivity and Specificity, Sentinel Lymph Node Biopsy
Pubmed
Open Access
Yes
Create date
04/11/2010 10:35
Last modification date
20/08/2019 16:00