A computer model of human atria with reasonable computation load and realistic anatomical properties
Details
Serval ID
serval:BIB_DB9C804FEACA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A computer model of human atria with reasonable computation load and realistic anatomical properties
Journal
IEEE Transactions on Biomedical Engineering
ISSN
0018-9294 (Print)
Publication state
Published
Issued date
11/2001
Volume
48
Number
11
Pages
1229-37
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and arterial embolisms. The aim of this work is to develop a simplified anatomical computer model of human atria for the study of atrial arrhythmias and the understanding of electrical propagation mechanisms. With the model we propose, up to 40 s of real-time propagation have been simulated on a single-processor computer. The size and the electrophysiological properties of the simulated atria are within realistic values and information about anatomy has been taken into account in a three-dimensional structure. Besides normal sinus beat, pathological phenomena such as flutter and fibrillation have been induced using a programmed stimulation protocol. One important observation in our model is that atrial arrhythmias are a combination of functional and anatomical reentries and that the geometry plays an important role. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing in great detail how arrhythmias are initiated and sustained. Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them.
Keywords
Atrial Fibrillation/physiopathology
Atrial Function
Biomedical Engineering
*Computer Simulation
Electrophysiology
Heart/*anatomy & histology/*physiology
Heart Atria/anatomy & histology
Humans
Models, Anatomic
*Models, Cardiovascular
User-Computer Interface
Pubmed
Web of science
Create date
15/02/2008 11:29
Last modification date
20/08/2019 16:00