Exercise efficiency relates with mitochondrial content and function in older adults.

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Serval ID
serval:BIB_DB98D79B5F3E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exercise efficiency relates with mitochondrial content and function in older adults.
Journal
Physiological Reports
Author(s)
Broskey N.T., Boss A., Fares E.J., Greggio C., Gremion G., Schlüter L., Hans D., Kreis R., Boesch C., Amati F.
ISSN
2051-817X (Electronic)
ISSN-L
2051-817X
Publication state
Published
Issued date
06/2015
Peer-reviewed
Oui
Volume
3
Number
6
Pages
9
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Chronic aerobic exercise has been shown to increase exercise efficiency, thus allowing less energy expenditure for a similar amount of work. The extent to which skeletal muscle mitochondria play a role in this is not fully understood, particularly in an elderly population. The purpose of this study was to determine the relationship of exercise efficiency with mitochondrial content and function. We hypothesized that the greater the mitochondrial content and/or function, the greater would be the efficiencies. Thirty-eight sedentary (S, n = 23, 10F/13M) or athletic (A, n = 15, 6F/9M) older adults (66.8 ± 0.8 years) participated in this cross sectional study. V˙O2peak was measured with a cycle ergometer graded exercise protocol (GXT). Gross efficiency (GE, %) and net efficiency (NE, %) were estimated during a 1-h submaximal test (55% V˙O2peak). Delta efficiency (DE, %) was calculated from the GXT. Mitochondrial function was measured as ATPmax (mmol/L/s) during a PCr recovery protocol with (31)P-MR spectroscopy. Muscle biopsies were acquired for determination of mitochondrial volume density (MitoVd, %). Efficiencies were 17% (GE), 14% (NE), and 16% (DE) higher in A than S. MitoVD was 29% higher in A and ATPmax was 24% higher in A than in S. All efficiencies positively correlated with both ATPmax and MitoVd. Chronically trained older individuals had greater mitochondrial content and function, as well as greater exercise efficiencies. GE, NE, and DE were related to both mitochondrial content and function. This suggests a possible role of mitochondria in improving exercise efficiency in elderly athletic populations and allowing conservation of energy at moderate workloads.
Pubmed
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-126339
Swiss National Science Foundation / Careers / PZ00P3-149398
Create date
17/06/2015 13:20
Last modification date
20/01/2020 7:20
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