Angiotensin II antagonists.
Details
Serval ID
serval:BIB_DB863DBD7E56
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiotensin II antagonists.
Journal
Clinical and experimental hypertension
ISSN
1064-1963
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
15
Number
6
Pages
1221-38
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
Acute blockade of the renin-angiotensin system with the parenterally active angiotensin II antagonist saralasin has been shown to effectively lower blood pressure in a large fraction of patients with essential hypertension and to improve hemodynamics in some patients with congestive heart failure. It is now possible to antagonize chronically angiotensin II at its receptor using the non-peptide angiotensin II inhibitor losartan (DuP 753, MK 954). When administered by mouth, this compound induces a dose-dependent inhibition of the pressor response to exogenous angiotensin II. This effect is closely related to circulating levels of the active metabolite E3174. Preliminary studies performed in hypertensive patients suggest that losartan has a blood pressure lowering action equivalent to that of an ACE inhibitor. Whether this compound will compare favorably with ACE inhibitors requires however further investigation.
Keywords
Angiotensin II, Animals, Biphenyl Compounds, Humans, Hypertension, Imidazoles, Losartan, Receptors, Angiotensin, Reference Values, Renin-Angiotensin System, Saralasin, Tetrazoles
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 16:00