Thrombin generation in a woman with heterozygous factor V Leiden and combined oral contraceptives: A case report.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_DB64EDD82D92
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Thrombin generation in a woman with heterozygous factor V Leiden and combined oral contraceptives: A case report.
Journal
Research and practice in thrombosis and haemostasis
Author(s)
Zermatten M.G., Bertaggia Calderara D., Aliotta A., Alberio L.
ISSN
2475-0379 (Electronic)
ISSN-L
2475-0379
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
4
Number
3
Pages
429-432
Language
english
Notes
Publication types: Case Reports
Publication Status: epublish
Abstract
Combined oral contraceptives and factor V Leiden mutation are multiplicative risk factors for venous thromboembolism. However, it remains unknown whether this multiplicative effect is reflected in thrombin generation assays. We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin (TM) sensitivity, compared to the control population. This profile possibly reflected a high thrombotic risk. After discontinuation of combined oral contraceptives, thrombin generation and TM sensitivity improved greatly, leaving only a slightly prothrombotic profile. Therefore, the multiplied thrombotic risk occurring with simultaneous combined oral contraceptives and factor V Leiden mutation is reflected by a thrombin generation assay performed without and with TM. This could be a promising tool to identify women taking combined oral contraceptives at high risk for venous thromboembolism. Further studies are needed to verify this hypothesis.
Keywords
contraception, factor V, thrombin, thromboembolism, thrombosis, venous
Pubmed
Web of science
Open Access
Yes
Create date
01/04/2020 18:21
Last modification date
30/04/2021 6:15
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