Exploring the role of white matter connectivity in cortex maturation.

Details

Ressource 1Download: journal.pone.0177466.pdf (2572.42 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_DB034F374B4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exploring the role of white matter connectivity in cortex maturation.
Journal
PloS one
Author(s)
Friedrichs-Maeder C.L., Griffa A., Schneider J., Hüppi P.S., Truttmann A., Hagmann P.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
12
Number
5
Pages
e0177466
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The maturation of the cortical gray matter (GM) and white matter (WM) are described as sequential processes following multiple, but distinct rules. However, neither the mechanisms driving brain maturation processes, nor the relationship between GM and WM maturation are well understood. Here we use connectomics and two MRI measures reflecting maturation related changes in cerebral microstructure, namely the Apparent Diffusion Coefficient (ADC) and the T1 relaxation time (T1), to study brain development. We report that the advancement of GM and WM maturation are inter-related and depend on the underlying brain connectivity architecture. Particularly, GM regions and their incident WM connections show corresponding maturation levels, which is also observed for GM regions connected through a WM tract. Based on these observations, we propose a simple computational model supporting a key role for the connectome in propagating maturation signals sequentially from external stimuli, through primary sensory structures to higher order functional cortices.

Pubmed
Web of science
Open Access
Yes
Create date
06/06/2017 21:18
Last modification date
20/08/2019 17:00
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