Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart.

Details

Serval ID
serval:BIB_DAFB009FA0BE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart.
Journal
Immunologic Research
Author(s)
Jamilloux Y., Gerfaud-Valentin M., Martinon F., Belot A., Henry T., Sève P.
ISSN
1559-0755 (Electronic)
ISSN-L
0257-277X
Publication state
Published
Issued date
2015
Volume
61
Number
1-2
Pages
53-62
Language
english
Abstract
Adult-onset Still's disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.
Keywords
Adult-onset Still's disease, Systemic-onset juvenile idiopathic arthritis, Autoinflammatory diseases, Reactive hemophagocytic lymphohistiocytosis, IL-1 beta, IL-18, Ferritin
Pubmed
Web of science
Create date
13/03/2015 18:57
Last modification date
20/08/2019 16:00
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