Fas-dependent tissue turnover is implicated in tumor cell clearance

Details

Serval ID
serval:BIB_DACA47BBF77F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Fas-dependent tissue turnover is implicated in tumor cell clearance
Journal
Oncogene
Author(s)
Schroter  M., Peli  J., Hahne  M., Tschopp  J., Reichmann  E.
ISSN
0950-9232 (Print)
Publication state
Published
Issued date
03/2000
Volume
19
Number
14
Pages
1794-800
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 30
Abstract
The apoptosis-inducing Fas receptor has been shown to be down-regulated in various types of tumors, while its ligand (FasL) appears to be frequently up-regulated. Here we provide evidence that there is a strong selective pressure in vivo against Fas-expressing, tumorigenic NIH3T3 cells, favoring survival, proliferation and eventually tumor formation by Fas-negative cells. Importantly, re-expression of Fas in these cells results in either the complete abolishment of tumor development, or in a significant extenuation of the latency period of tumor outgrowth. In addition, we found that environmental conditions which prevail during tumorigenesis, such as limiting amounts of survival factors and the lack of cell adhesion, are markedly sensitizing tumor cells to Fas-mediated suicide. Our data suggest that in addition to T cell-mediated immune responses, mechanisms of Fas-dependent tissue turnover are also centrally implicated in tumor cell clearance.
Keywords
3T3 Cells Animals Antigens, CD95/*metabolism Carcinogenicity Tests Cell Transplantation Culture Media Fas Ligand Protein Membrane Glycoproteins/*metabolism/pharmacology Mice Mice, Nude Neoplasms, Experimental/*physiopathology Serum Albumin, Bovine/pharmacology
Pubmed
Web of science
Create date
24/01/2008 16:18
Last modification date
03/03/2018 21:55
Usage data