Involvement of granule proteins in T-cell-mediated cytolysis

Details

Serval ID
serval:BIB_DA9D2D190975
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Involvement of granule proteins in T-cell-mediated cytolysis
Journal
Natural Immunity and Cell Growth Regulation
Author(s)
Krahenbuhl  O., Tschopp  J.
ISSN
0254-7600 (Print)
Publication state
Published
Issued date
1990
Volume
9
Number
4
Pages
274-82
Notes
Journal Article
Review
Abstract
Cytolytic T lymphocytes (CTL) and large granular lymphocytes contain dense cytoplasmic granules which, when isolated, are lytic for a variety of target cells. Granule proteins are released from the effector cell upon target cell interaction, further suggesting that they play a role in the cytolytic mechanism. Major proteins in CTL granules are a family of serine esterases (granzymes) and a pore-forming protein called perforin (cytolysin). Despite structural similarities between functionally conserved regions of perforin and the ninth component of complement (C9), these two lytic molecules are clearly distinct in their mode of target cell recognition. Perforin, unlike C9, is not dependent on a protein receptor molecule but binds to the target cell membrane via phosphorylcholine in a Ca2(+)-dependent manner. Here, we discuss the stimulus-secretion model for T-cell-mediated cytotoxicity with respect to our current understanding of perforin and the granzyme proteases.
Keywords
Animals Cytoplasmic Granules/*immunology Cytotoxicity, Immunologic/immunology Granzymes Humans *Membrane Glycoproteins Membrane Proteins/immunology Pore Forming Cytotoxic Proteins Serine Endopeptidases/immunology T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 15:59
Usage data