New concepts in the pathophysiology of infective endocarditis.

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Serval ID
serval:BIB_DA4BA27157AE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New concepts in the pathophysiology of infective endocarditis.
Journal
Current Infectious Disease Reports
Author(s)
Widmer E., Que Y.A., Entenza J.M., Moreillon P.
ISSN
1523-3847[print], 1523-3847[linking]
Publication state
Published
Issued date
2006
Volume
8
Number
4
Pages
271-279
Language
english
Abstract
Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, becoming embedded and protected from host defenses. Staphylococcus aureus also actively invade the endothelium, causing apoptosis and endothelial damage. Knowledge of this interplay identifies host factors as potential therapeutic targets. Blocking infection by modulating host factors might be opportune because host factors are conserved. In contrast, interfering with bacterial virulence factors might be more complicated because they vary among different bacteria.
Pubmed
Open Access
Yes
Create date
07/04/2008 7:46
Last modification date
01/10/2019 6:19
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