Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_DA41E4C0E1FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels.
Journal
American Journal of Epidemiology
Author(s)
Conen D., Vollenweider P., Rousson V., Marques-Vidal P., Paccaud F., Waeber G., Bochud M.
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
172
Number
12
Pages
1431-1441
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Elevated levels of γ-glutamyltransferase (GGT) have been associated with elevated blood pressure (BP) and diabetes. However, the causality of these relations has not been addressed. The authors performed a cross-sectional analysis (2003-2006) among 4,360 participants from the population-based Cohorte Lausannoise (CoLaus) Study (Lausanne, Switzerland). The rs2017869 variant of the γ-glutamyltransferase 1 (GGT1) gene, which explained 1.6% of the variance in GGT levels, was used as an instrument for Mendelian randomization (MR). Sex-specific GGT quartiles were strongly associated with both systolic and diastolic BP (all P's < 0.0001). After multivariable adjustment, these relations were attenuated but remained significant. Using MR, the authors observed no positive association of GGT with BP (systolic: β -5.68, 95% confidence interval (CI): -11.51, 0.16 (P = 0.06); diastolic: β = -2.24, 95% CI: -5.98, 1.49 (P = 0.24)). The association of GGT with insulin was also attenuated after multivariable adjustment but persisted in the fully adjusted model (β = 0.07, 95% CI: 0.04, 0.09; P < 0.0001). Using MR, the authors also observed a positive association of GGT with insulin (β = 0.19, 95% CI: 0.01, 0.37; P = 0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP.
Keywords
Adult, Aged, Causality, Cross-Sectional Studies, Diabetes Mellitus, Type 2/enzymology, Diabetes Mellitus, Type 2/epidemiology, Female, Humans, Hypertension/enzymology, Hypertension/epidemiology, Insulin/blood, Insulin Resistance/physiology, Male, Mendelian Randomization Analysis, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, gamma-Glutamyltransferase/genetics, gamma-Glutamyltransferase/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
04/11/2010 13:47
Last modification date
20/08/2019 15:59
Usage data