A mathematical model of pathogenesis in idiopathic parkinsonism

Details

Serval ID
serval:BIB_DA41931898E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A mathematical model of pathogenesis in idiopathic parkinsonism
Journal
Brain
Author(s)
Schulzer  M., Lee  C. S., Mak  E. K., Vingerhoets  F. J., Calne  D. B.
ISSN
0006-8950 (Print)
Publication state
Published
Issued date
06/1994
Volume
117 ( Pt 3)
Pages
509-16
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
We used our observations relating clinical deficits in idiopathic parkinsonism (IP) to age and to disease duration (Lee et al, Brain 1994; 117: 501-7), to develop a mathematical model of the temporal profile of neurodegeneration in IP. We also examined other sets of relevant published observations and applied three additional assumptions which permitted the formulation of this model. Our model indicates that accelerating or decelerating processes should be excluded as the driving forces behind neuronal death in IP. Mechanisms in accord with the model include: (i) an event that kills some neurons and damages others in such a way that their life expectation is reduced; or (ii) an event that starts a process which is continuously killing healthy neurons at a constant rate. The model enables us to extrapolate back to estimate when the causal event occurred. It also explains why IP proceeds more rapidly in older patients. The model has potential relevance to other neurodegenerative disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis.
Keywords
Adult Aged *Aging Algorithms Humans Middle Aged *Models, Theoretical Parkinson Disease/*etiology/*physiopathology
Pubmed
Web of science
Create date
25/01/2008 12:49
Last modification date
20/08/2019 15:59
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